I gave a 60-minute talk on Architecting for the enterprise with JavaScript. It covers my experience building out systems and UIs for MLS in a single language environment and what challenges and benefits we encountered.
https://www.oreilly.com/library/view/oreilly-software-architecture/9781491976142/video289800.html
https://www.oreilly.com/library/view/oreilly-software-architecture/9781491976142/video289800.html